The current proposal aims to investigate the impact of acute stress on the fetal autonomic nervous system.
Over the last decades there is growing evidence that increased maternal stress levels lead to an adverse effect on the physiological, metabolic and neuronal development of the fetus during gestation with possible long-lasting effects. Several studies showed that maternal stress also affects fetal endocrine processes during pregnancy and increases the risk for childhood and adult obesity. Thus, the aim of the study is to investigate the effect of acute stress related to the action of the artificial glucocorticoid betamethasone on fetal heart and brain activity. The fetal activity will be measured with biomagnetic sensors.
Study Type
OBSERVATIONAL
Enrollment
24
First measurement: 12-36 hours after betamethasone treatment Second measurement: within five days after betamethasone treatment and two weeks Third measurement (neonatal measurement): 1-8 weeks after birh
University Hospital Tuebingen, Department of Women's Health
Tübingen, Germany
RECRUITINGfetal and maternal heart rate
Measurement by fMEG
Time frame: 8 weeks
fetal and neonatal brain activity in response to auditory and visual stimuli
Measurement by fMEG
Time frame: 8 weeks
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