Systolic Time Intervals a Prognostic Tool of Heart Failure in Emergency Departement (STI/AHF)

University of Monastir642 enrolled

Overview

The performance of STIs and clinical scores alone and their combination to predict short term prognosis of acute decompensated heart failure.

Acute heart failure is a leading cause of hospitalization and death.Prediction of these adverse events is still challenging. STI is an old technique based on the recording of two parameters: electrocardiogram and phonocardiogram, and from them measuring the different systolic intervals: pre-ejection period (PEP),electro-mechanic activation time (EMAT), Left ventricular ejection time (LVET) and systolic time ratio (RTS) were measured. The aim of these study is to demonstrate whether systolic time intervals (STIs) can improve clinical scores EFFECT (Enhanced Feedback for Effective Cardiac Treatment) and GWTG-HF (Get With the Guidelines-Heart Failure) for predicting 30 day mortality and readmission in patients with acute decompensated heart failure (ADHF) in the ED.

Study Type

OBSERVATIONAL

Enrollment

642

Conditions

Dyspnea Heart Failure

Interventions

biopacDEVICE

Acoustic cardiography was performed for all participants using the BIOPAC system with "Student Lab" software version 3.7.2. An electrocardiogram was obtained by two electrodes placed at the right upper limb and the lower left limb. Simultaneously heart sounds were recorded with a specific sensor placed at the mitral focus.

prognostic scoresDIAGNOSTIC_TEST

Effect and GWTGHF were calculated for every patient

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * non traumatic dyspnea * age more than 18 years old. Exclusion Criteria: * ECG diagnostic for acute myocardial infarction * ischemic chest pain within the prior 24 hours * history of a heart transplant * pericardial effusion * chest wall deformity suspected of causing dyspnea * coma * shock,Mechanical Ventilation, vasopressor drugs * arrhythmia serious and sustained, * pace maker * severe mitral valve disease, * severe pulmonary arterial hypertension * renal failure with creatinine \>350micromol/l

Locations (1)

Emergency department of university hospital Fattouma Bourguiba of Monastir Monastir, Monastir Tunisia

Monastir, Tunisia

Outcomes

Primary Outcomes

compare the STIs prognostic performance against clinical scores

the area under ROC curve of the Systolic Time Intervals compared to the one of the EFFECT and GWTG HF scores

Time frame: 30 days

Secondary Outcomes

compare the STI prognostic performance between HFpEF and HFrEF patients

compare the STI prognostic performance between HFpEF and HFrEF patients using the area under curve estimation of the ROC curve of the three systolic time intervals (PEP;EMAT measured in milliseconds,and PEP/EMAT) of the two groups

Time frame: 30 days

Data from ClinicalTrials.gov

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