In the pre-hospital setting, the severity assessment of septic shock is essential to decide the optimal initial in-hospital level of care. As clinical signs can be faulted, there is a need for an additional element in order to enhance the severity assessment and to decide in-hospital admission in the intensive care unit (ICU) or in the emergency department (ED). Point of care medical device yielding blood lactate levels since the pre-hospital setting may give an easy and valuable element for the severity assessment and the decision-making. The aim of this study is to provide clinical evidence that the pre-hospital blood lactate level predicts the 30-day mortality of patients with septic shock.
This trial is a prospective, observational, non-randomized controlled study. A total of 1000 patients requiring mobile intensive care unit intervention for a septic shock in the pre-hospital setting will be included. Pre-hospital blood lactate levels will not be taken into account to decide patients treatments and/or ED or ICU admission. In the pre-hospital setting, each patient will benefit from 2 measurements of blood lactate level: initial measurement at the first contact, and final measurement at the hospital admission with a specific point of care medical device.
Study Type
OBSERVATIONAL
Enrollment
1,000
Patients meeting the inclusion criteria and none of the non-inclusion criteria will benefit from 2 venous blood samples in order to precise the initial blood lactate level, e.g. at the first medical contact, and the final blood lactate level, e.g. at the hospital admission.
APHP Necker Enfants Malades
Paris, France
RECRUITINGMortality after inclusion
mortality rate
Time frame: 30 days
Intensive Care Unit length of stay
Duration of ICU length of stay
Time frame: 90 days
Hospital length of stay
Duration of Hospital length of stay
Time frame: 90 days
Mechanical ventilatory support
Duration of mechanical ventilation
Time frame: 30 days
Hemodynamic support
Duration of catecholamines' infusion
Time frame: 30 days
Duration of hemodiaflitration
Duration of extra renal support
Time frame: 30 days
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