Definition and Validation of Normative Data of EndoFLIP™ Measurements in Healthy Subjects

Inclusion Criteria: 1. Healthy male or female ages 18-75 years. 2. The subject has the ability to give informed consent. 3. The subject has the ability to undergo sedation, as assessed and determined by the treating physician or the anesthesiologist. 4. BMI range of 18-30 kg/m2. 5. Asymptomatic subjects as assessed by gastro-esophageal reflux disease questionnaire (GERDQ) negative score of less than 8 points (GERDQ \<8) and brief esophageal dysphagia questionnaire (BEDQ) negative score of 0 points (BEDQ score=0), as assessed and determined by treating physician. Exclusion Criteria: 1. Subject has known or suspected major gastrointestinal motility disorders including but not limited to major esophageal motility disorders, EGJ outflow obstruction and delayed gastric emptying. 2. Subject has dysphagia or any swallowing disorder. 3. Subject has an inability to tolerate nasal intubation. 4. Subject has a known or suspected bleeding diathesis. 5. Subject with known or suspected Gastroesophageal Reflux Disease (GERD), or subject has symptoms of GERD. 6. The subject has a known or suspected esophageal disease or disorder such as eosinophilic esophagitis (EOE), Barretts esophagus, severe esophagitis, upper GI bleeding or esophageal varices. 7. Subject is known or is suspected to suffer from an esophageal stricture or obstruction. 8. Subject has a hiatal hernia. 9. Subject with medical comorbidities such as diabetes, hypertension hyper/hypothyroidism, or chronic obstructive pulmonary disease (COPD) 10. Subject with a diagnosed autoimmune disease. 11. Subject who has undergone prior upper GI surgery or interventions such as esophageal myotomy, fundoplication, dilatation or stent. 12. Subject has a history of any malignancy. 13. Subject has a history of any seizure disorder. 14. Subject has a history of an eating disorder/s. 15. Subject has an active history of nicotine use, cannabis use or alcohol abuse (as defined by: greater than 14 drinks/week or 4 drinks/day for men, 7 drinks/week or 3 drinks/day for women. A standard drink is defined as 12 oz of beer, 5 oz of wine, or 1.5 oz of liquor). Subject has used any tobacco, nicotine or cannabis products in the last 6 months or has abused alcohol in the last 6 months. 16. Subject taking or prescribed or over-the-counter any acid suppressant medications (for example proton-pump inhibitors), any medication that treats reflux or heartburn symptoms (for example Tums and Maalox), any anticoagulant medications, any opiate medication or medication with known impact on GI motility. 17. Subject has any allergy or other contraindication to the device components or to study medication used prior and/or during the procedure. 18. Subject has a known sensitivity or allergy to nickel or other heavy metals. 19. Subject has any condition, which according to the investigators judgment, precludes compliance with study and/or device instructions. 20. Females who are pregnant or nursing at the time of screening and/or during the study period or are sexually active and of child bearing potential without medically acceptable methods of contraception. 21. Subject who has a cardiac pacemaker or implantable cardiac defibrillator. 22. Subject who has a general contraindication for upper endoscopy. 23. Subject who is currently participating in another clinical study (investigational drug or device). 24. Subject who is considered to be part of a vulnerable population (e.g. prisoners or those without sufficient mental capacity). 25. Medtronic employees.