The current trial is intended to assess the efficacy of oral versus vaginal progesterone for luteal support in frozen IVF cycles.
Progesteron is used for luteal phase support in IVF cycles. Progesterone can be administered vaginally and orally. Duphaston is an oral progesterone drug, which has recentlly been proven effective in fresh cycle IVF. Yet, less is known regarding its efficacy in frozen cycle IVF. Thus, the objective of our trial is to compare the efficacy of vaginal and oral progesterone in frozen IVF cycles.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
100
Oral progesterone 10 mg TID
Vaginal Endometrin 100 mg twice daily
Edith Wolfson Medical Center
Holon, Israel
RECRUITINGLive birth rate
Birth of a live infant after 24 weeks gestation
Time frame: Up to 9 months
Clinical pregnancy rate
Viable pregnancy as demonstrated by ultrasound
Time frame: Outcome assesed 6-7 weeks following treatment
Implantation rate
Number of gestational sacs divided by number of embryos transferred (percentage)
Time frame: Outcome assessed 6-7 weeks following treatment
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