This study evaluates the effect of 5Hz repetitive Transcranial Magnetic Stimulation (rTMS) on Dorsomedial Prefrontal Cortex on Borderline Personality Disorder (BPD).
Borderline Personality Disorder (BPD) is a mental illness with a high worldwide prevalence and economic costs, and is characterized with impulsiveness, both interpersonal relationships and emotional disturbance. Symptoms are related to hypofunction of frontal areas like Dorsomedial Prefrontal Cortex (DMPFC). Psychotherapy is the base treatment in this disease, but economic costs and long-time therapy have made difficult the attachment. Repetitive Transcranial Magnetic Stimulation(rTMS), authorized by Food and Drug Administration (FDA) on Major Depressive Disorder (MDD) treatment has proven good results in previous works in BPD clinical characteristics on both dorsolateral prefrontal cortex (DLPFC) and enhancement in depressive symptoms stimulating DMPFC in high frequency. However, there are no current research that have addressed the use of low-frequency on this anatomical area.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
20
Subjects will receive both active and placebo rTMS, in a crossover modality.
Autonomous University of Queretaro
Querétaro City, Querétaro, Mexico
RECRUITINGBorderline Symptoms List (BSL)
BSL is a 23 item scale that evaluates the general symptoms and 11 items with behavioural evaluation of BPD.
Time frame: 6 weeks
Global Clinical Impression of BPD (GCI-BPD)
CGI-BPD is a 10 item evaluation that rates the severity of BPD distributed in 9 neuropsychological domains with a final global score.
Time frame: 6 weeks
Borderline Evaluation of Severity Over Time (BEST)
BEST is a 15 item scale that evaluates the severity in this pathology according to 3 areas: thoughts, emotions and typical behaviours.
Time frame: 6 weeks
Hamilton Depression Rating Scale (HDRS)
HDRS is a 21 item scale that evaluates the severity of depressive symptoms in patients.
Time frame: 6 weeks
Hamilton Anxiety Rating Scale (HARS)
HARS is a 14 items rating scale that evaluates the severity of anxiety symptoms in patients.
Time frame: 6 weeks
Barratt Impulsivity Scale (BIS-11)
The Barratt Impulsiveness Scale is a questionnaire designed to assess the personality / behavioral construct of impulsiveness; composed of 30 items describing common impulsive or non-impulsive (for reversed scored items) behaviors and preferences .
Time frame: 6 weeks
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