The Impact of Three Distinct Exercise Types on Fatigue, Anxiety, and Depression in Parkinson's Disease

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Overview

The purpose of the study is to learn about the impact of exercise on fatigue, anxiety, and depression in Parkinson's disease. It is well established that exercise improves the motor symptoms of Parkinson's disease. However, it is not clear which types of exercise are most beneficial for specific non-motor symptoms.

This is a multi-site trial (12 patients in each site). The investigators are recruiting 24 patients who will be randomized into either a spinning class, yoga class, dance class, or no exercise intervention. Classes will be conducted twice a week for 6 weeks total at times convenient for the patients. Patients will also be asked to complete questionnaires after exercise classes to see if the exercise intervention improves measures of fatigue, anxiety, and depression - and what exercise intervention may be superior. All participants will be asked to complete questionnaires each week and will be asked to wear a "Microsoft exercise band" during the course of the study. Use of the exercise band is optional.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Parkinson Disease

Interventions

Spinning ClassBEHAVIORAL

Spinning Class twice a week for six weeks.

Yoga ClassBEHAVIORAL

Yoga Class twice a week for six weeks.

Dance ClassBEHAVIORAL

Dance Class twice a week for six weeks.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Subjects diagnosed with Idiopathic Parkinson's Disease 2. Age between 18 - 75 years 3. Hoehn and Yahr stage less than or equal to 3 4. Mini-Mental State Exam (MMSE) score of over 23 at screening 5. If subjects are taking any medications for depression, fatigue, or anxiety, regimen must be stable for 8 weeks prior to baseline visit 6. Subjects willing and able to give informed consent Exclusion Criteria: 1. Subjects with a diagnosis of an atypical Parkinsonism 2. Subjects unwilling or unable to obtain Health Waiver from Primary Care Provider 3. Score of 60 or more on UPDRS III at screening 4. Scores in the 'normal' range on all three study assessments: Beck Depression Index II, Fatigue Severity Scale, and Zung self-rating Anxiety Scale 5. Participation in any of the 3 physical activities more than 3 times in the past for 8 weeks prior to baseline 6. Any other reason that, in the investigator's opinion, would exclude the subject from participation in the study

Locations (2)

Dartmouth-Hitchcock Medical Center

Lebanon, New Hampshire, United States

Premier Health

Dayton, Ohio, United States

Outcomes

Primary Outcomes

Change from baseline, if any, in subjects' Fatigue Severity Scale

Subjects will complete the Fatigue Severity Scale at screening and once per week during the exercise class session. Subjects also will receive a follow-up questionnaire to be completed 1 month after the class sessions end. Each item is scored from 1(strongly disagree) to 7(strongly agree).

Time frame: screening through study completion, up to 18 weeks

Change from baseline, if any, in subjects' Zung self-report Anxiety Scale

Subjects will complete the Zung self-report Anxiety Scale at screening and once per week during the exercise class session. Subjects also will receive a follow-up questionnaire to be completed 1 month after the class sessions end. Each item is scored from 1(a little of the time) to 4(most of the time).

Time frame: screening through study completion, up to 18 weeks

Change from baseline, if any, in subjects' Beck Depression Inventory II scale

Subjects will complete the Beck Depression Inventory II at screening and once per week during the exercise class session. Subjects also will receive a follow-up questionnaire to be completed 1 month after the class sessions end. Each item is scored from 0(Normal) to 3(Severe).

Time frame: screening through study completion, up to 18 weeks

Data from ClinicalTrials.gov

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