Study of TOP1630 for Dry Eye Syndrome

Inclusion Criteria: * Be at least 18 years of age; * Provide written informed consent; * Have a reported history of dry eye; * Have a history of use of eye drops for dry eye symptoms; Symptoms of dry eye syndrome including: * Ocular discomfort * Conjunctival redness * Tear film break up time * Schirmer test score Signs of dry eye syndrome including: * Conjunctival staining score Exclusion Criteria: * Have any clinically significant slit lamp findings at entry visit ; * Be diagnosed with an ongoing ocular infection; * Have any significant ocular lesion that could interfere with assessment of safety or efficacy or prevent study conduct in the opinion of the PI; * Have any planned ocular and/or lid surgeries over the study period; * Have an uncontrolled systemic disease; * Be a woman who is pregnant, nursing or planning a pregnancy; * Be a woman of childbearing potential who is not using an acceptable means of birth control; * Have a known allergy and/or sensitivity to the test article or its components; * Have a condition or be in a situation which the investigator feels may put the subject at significant risk, may confound the study results, or may interfere significantly with the subject's participation in the study