The current study aims to assess the effect of assisted hatching on the implantation rate of frozen blastocytes.
The Zona Pellucida protects the ovum from the penetration of multiple sperm, and from mechanical and physiological damage until the fertilized ovum reaches the uterus. Subsequently, spontaneous hatching occurs, and enables the embryo to attach to the endometrium. The technique of assisted hatching was originally investigated as a means to improve implantation in cases of zona hardening, and is commonly performed in 3-day embryos. In the current study, the investigators aim to investigate the effect of assisted hatching on 5-day frozen embryos.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
84
Controlled hatching of the zona pellucida in the laboratory prior to embryo transfer
Edith Wolfson Medical Center
Holon, Israel
RECRUITINGImplantation rate
Number of gestational sacs demonstrated on ultrasound divided by the number of embryos transferred (expressed as percentage)
Time frame: Five to six weeks following embryo transfer
Chemical pregnancy
Increase and subsequent decrease in beta HCG levels with no evidence of gestational sac on ultrasound
Time frame: Five to six weeks following embryo transfer
Early spontaneous abortion
Spontaneous abortion of pregnancy during the first trimester of pregnancy
Time frame: Up to 15 weeks from embryo transfer
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.