Impact of Coenzyme Q10 and Selenium on Seminal Fluid and Semen Antioxidant Status

University of Sumer70 enrolled

Overview

The study was conducted to assess the impact of coenzyme Q10 and selenium on seminal fluid parameters and antioxidant status in infertile men.

The aim of this study was to assess the impact of coenzyme Q10 and selenium on seminal fluid parameters and antioxidant status in infertile men with idiopathic oligoasthenoteratospermia.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Male Infertility

Interventions

Coenzyme Q10DIETARY_SUPPLEMENT

Coenzyme Q10

SeleniumDIETARY_SUPPLEMENT

Selenium

Eligibility

Sex: MALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * History of infertility of at least 12 months despite regular unprotected intercourse. * Oligoasthenoteratospermia was diagnosed by semen analysis showing abnormal sperm concentration (\<15 million/ml), progressive motility (\<32%), total motility (\<40%) and morphology (\<30% WHO criteria) as defined by WHO manual for semen analysis 2010 Exclusion Criteria: * Azoospermia, * Varicocele, * Genital tract infection, * Cryptorchidism, * Testicular trauma or scrotal surgery, * Endocrine disorder, * Systemic illness, * Smoking * The presence of female factor

Locations (1)

Fertility Unit, Babyl

Hillah, Iraq

Outcomes

Primary Outcomes

Semen volume (WHO 2010 guidelines)

Semen volume in ml

Time frame: 3 months

Sperm concentration in semen (WHO 2010 guidelines)

Sperm concentration in million/ml

Time frame: 3 months

Sperm motility in semen (WHO 2010 guidelines)

Sperm motility (%)

Time frame: 3 months

Sperm morphology in semen (WHO 2010 guidelines)

Normal sperm morphology (%)

Time frame: 3 months

Seminal plasma TAC (Colorimetric assays)

Seminal plasma total antioxidant capacity in mmol/ml

Time frame: 3 months

Seminal plasma CAT (Colorimetric assays)

Seminal plasma catalase in U/ml

Time frame: 3 months

Seminal plasma SOD (Colorimetric assays)

Superoxide dismutase in U/ml

Time frame: 3 months

Data from ClinicalTrials.gov

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