Randomized, controlled, double blind clinical trial. Adult patients admitted to the ICU of the Hospital Español de México with a diagnosis of septic shock will be included. Patients will be randomized to one of the study groups: Intervention Group: Vitamin C 6 grams in 250 ml of 0.9% saline solution every 24 hours, in continuous infusion for 72 hours. Placebo Group: 0.9% saline solution 250 ml every 24 hours, in continuous infusion for 72 hours.
Randomized, controlled, double blind clinical trial. Adult patients admitted to the ICU of the Hospital Español de México with a diagnosis of septic shock will be included. Patients will be randomized to one of the study groups: Intervention Group: Vitamin C 6 grams in 250 ml of 0.9% saline solution every 24 hours, in continuous infusion for 72 hours. Placebo Group: 0.9% saline solution 250 ml every 24 hours, in continuous infusion for 72 hours. Bottles will be identical, only identified by the sequential number of the patient that has been included. Primary objective is to demonstrate that the administration of intravenous Vitamin C decreases the dose of exogenous vasopressors in patients with septic shock
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Hospital Español
Mexico City, Mexico
Vasopressor dose
Hourly dose of exogenous vasopressor
Time frame: 72 hours
Hours of vasopressor use
Total hours of vasopressor use
Time frame: through study completion, an average of 30 days
Days of mechanical ventilation
Total days of mechanical ventilation use
Time frame: through study completion, an average of 30 days
Days of Intensive Care Unit stay
Total days of intensive care unit stay
Time frame: through study completion, an average of 30 days
Mortality in Intensive Care Unit
Rate of intensive care mortality
Time frame: through study completion, an average of 30 days
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