Cyanoacrylate Closure Versus Surgical Stripping for Incompetent Saphenous Veins

Inclusion Criteria: * Age between 18 and 80 years of age at the time of enrollment * Reflux in great saphenous vein greater than 0.5 seconds after distal compression and release or Valsalva's maneuver in the standing or reverse Trendelenburg position * Diameter of saphenous vein between 2mm to 20mm (with standing position) * One or more of the following symptoms related to the incompetent saphenous vein: aching, throbbing, heaviness, fatigue, pruritus, night cramps, restlessness, generalized pain or discomfort, swelling * Clinical, Etiologic, Anatomic, and Pathophysiologic classification of C2 through C5 Exclusion Criteria: * Previous treatment in targeted vein segment * Tortuous vein in which the delivery catheter cannot be inserted * Aneurysm of target vein segment \>20 mm * Daily use of narcotic or nonsteroidal anti-inflammatory pain medications to control pain associated with greater saphenous vein reflux * Known hypercoagulable disorder * Active malignancy * Regular use of systemic anticoagulation * Current use of systemic anticoagulant * Previous deep vein thrombosis/pulmonary embolism or active acute superficial thrombophlebitis * Unable to comply with the schedule and protocol evaluations * Unable to ambulate * Currently pregnant or breast feeding * Known sensitivity to cyanoacrylate adhesives * Symptomatic peripheral arterial disease with ankle-brachial index \<0.9 * Participation in another clinical study that has not reached primary endpoint within 30 days prior to enrollment * Any condition which in the opinion of the investigator could compromise subject safety or adherence to the protocol