Clinical Validation of the InterVenn Ovarian CAncer Liquid Biopsy

Inclusion Criteria: * Women age 18 years or older * Able to provide a written informed consent and who understand and agree to all study procedures required * A newly diagnosed adnexal mass as confirmed by imaging (computed tomography, ultrasonography, or magnetic resonance imaging) prior to enrollment * Planned diagnostic procedure or surgery by the subject's physician to remove adnexal masses within 90 days of imaging. (Note that diagnostic procedure typically includes biopsy (needle core or laparoscopic-directed), ascites cytology, pleural effusion cytology or FNA) Exclusion Criteria: * Had/Has a diagnosis of invasive malignancy (exception: non-melanoma skin cancers) in the previous 5 years. * Currently receiving or ever received any of the following prior cancer therapies in the previous 5 years. This includes curative surgical resection, local or systemic chemotherapy, targeted therapy, immunotherapy including cancer vaccines, hormone therapy, and/or radiation therapy. * Pregnancy * Current febrile illness * Acute exacerbation or flare of an inflammatory condition requiring escalation in therapy * Recipient of organ transplant * Poor health status or unfit to tolerate blood draw In addition, this study will include a small subgroup of women with a newly diagnosed clinically benign adnexal mass(es) for whom surgery is not planned as determined by the treating physician. This subgroup will follow the same exclusion criteria as listed above.