This research is being done to see if there is a difference between two different spinal anesthetics (Mepivacaine vs. Bupivacaine) as it relates to reducing post-operative complications and the time it takes for subjects to regain mobility after surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
154
10 mg (2 mL of 0.5%) administered as an isobaric spinal anesthetic
70 mg (3.5 mL of 2%) administered as an isobaric spinal anesthetic
Mayo Clinic in Rochester
Rochester, Minnesota, United States
Time to Return of Lower Extremity Motor Function
Assessed by measuring time from spinal anesthetic administration to postoperative achievement of Bromage 0 function (return of spontaneous ankle, knee, and hip movement) in the non-operative extremity at 15-minute intervals.
Time frame: Post surgery, approximately 1 day
Post-Anesthesia Care Unit (PACU) Length of Stay
Number of minutes subjects were admitted to PACU following the surgical procedure
Time frame: Time of discharge, approximately 1-2 days
Hospital Length of Stay
Number days subjects were admitted to the hospital following the surgical procedure
Time frame: Time of discharge, approximately 1-2 days
Maximum Pain Score
Measured on a scale from 1 to 10 in the first 24 hours following the surgical procedure, 1=mild pain; 10=worst pain.
Time frame: 24 hours following the surgical procedure
Median Pain Score
Measured on a scale from 1 to 10 in the first 24 hours following the surgical procedure, 1=mild pain; 10=worst pain.
Time frame: 24 hours following the surgical procedure
Discharge Pain Score
Measured on a scale from 1 to 10 at time of hospital discharge, 1=mild pain; 10=worst pain.
Time frame: Time of discharge, approximately 1-2 days
Orthostatic Hypotension
Number of participants to experience orthostatic hypotension following the surgical procedure.
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Time frame: Time of discharge, approximately 1-2 days
Urinary Retention
Number of participants to experience urinary retention follow the surgical procedure.
Time frame: Time of discharge, approximately 1-2 days
Transient Neurologic Symptoms
Number of participants to report transient neurologic symptoms
Time frame: One week post-operative