This is a prospective study that aimed to observe the therapeutic effects of minor salivary gland transplantation for cicatrizing conjunctivitis patients.
Cicatrizing conjunctivitis can be the common presentation of many ocular surface diseases as Stevens-Johnson syndrome (SJS), mucous membrane pemphigoid (MMP), chemical burn, Sjogren syndrome, chronic graft-versus-host disease (GVHD) and ocular trauma. Ocular dryness in combination with symblepharon and corneal opacity in these patients could lead to the poor visual and life quality, and less favorable prognosis of ocular reconstruction. This study aims to prospectively evaluate the therapeutic effects of minor salivary gland transplantation for cicatrizing conjunctivitis. The investigators evaluate the saliva-tear productivity (functional outcome) and the survival of graft (anatomical outcome) every three months. The investigators would also validate whether minor salivary gland transplantation is beneficial for the participant prior to further ocular reconstruction as limbal transplantation and corneal grafting.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
30
The investigators will harvest the autologous labial salivary gland tissue and transplant to the upper and lower conjunctival fornix of the lesion eye.
Department of Ophthalmology, National Taiwan University Hospital
Taipei, Taiwan
RECRUITINGthe change of Schirmer's test result (basic tear secretion in mm) from baseline to 12 months after operation
to compare the Schirmer's test between baseline and 12 months after operation. The higher Schirmer's test results, the better tear secretion function.
Time frame: the Schirmer's test will be performed every three months until 12 months after operation
the change of ocular surface disease index (OSDI) ( ranged from 0-100) from baseline to 12 months after operation
to compare the OSDI between baseline and 12 months after operation. The higher the OSDI value, the worse of subjective ocular surface disease related symptoms.
Time frame: the OSDI will be monitored every three months until 12 months
the change of chronic ocular complication score (COCS) ( ranged from 0-12) from baseline to 12 months after operation
to compare the COCS between baseline and 12 months after operation. The higher the COCS scores, the more ocular surface complications.
Time frame: the COCS will be monitored every three months until 12 months after operation
the change of conjunctival impression cytology scores (ranged from 0-5) from baseline to 12 months after operation
to compare the scores of conjunctival impression cytology between baseline and 12 months after operation. The higher the conjunctival impression cytology scores, the worse squamous metaplasia of the ocular surface.
Time frame: the impression cytology will be performed every three months until 12 months after operation
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