Clinical evaluation of local administration of injectable PRF (injectable platelet-rich fibrin) in periodontal pockets as adjunctive therapy to scaling and root planing. 15 periodontal patients will receive a through traditional mechanical treatment (scaling and root planing). Each patient will receive subgingival i-PRF injected in half mouth and the opposite side will be injected with saline, immediately after the deep scaling session.
The aim of the study is to evaluate the efficacy of i-PRF subgingival injection right after scaling and root planing as adjunctive therapy to traditional mechanical therapy. 15 periodontal patients will receive traditional mechanical supra and subgingival scaling and root planing. I-PRF will be applied subgingivally in the deep pockets in a half mouth design. The injected half mouth (study group) for each patient will be allocated randomly. The opposite side will be injected with saline (control group). Clinical parameters will be evaluated: plaque index (PI), bleeding on probing (BOP), probing depth (PD), clinical attachment level (CAL). Clinical measurements will be performed at baseline and at 8 weeks.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
15
Syrian Private University
Damascus, Syria
Clinical attachment level (CAL)
measure as the change in distance from the cementoenamel junction to the bottom of the gingival sulcus by using a periodontal probe (UNC 15 "University of North Carolina")
Time frame: baseline, 2 months
Probing pocket depth (PD)
measure as the change in distance from the gingival margin GM to the bottom of the gingival sulcus by using a periodontal probe (UNC 15 "University of North Carolina")
Time frame: baseline, 2 months
full mouth Plaque Index Quigely Hein Index (modified by Turesky et al, 1970)
0 No plaque 1. Separate flecks of plaque at the cervical margin of the tooth 2. A thin continuos band of plaque (up to one mm) at the cervical margin of the tooth 3. A band of plaque wider than one mm but covering less than one-third of the crown of the tooth 4. Plaque covering at least one-third but less than two-thirds of the crown of the tooth 5. Plaque covering two-thirds or more of the crown of the tooth labial/ buccal and lingual surfaces are assessed after using disclosing solution. An index for the entire mouth is determined by dividing the total score by the number surfaces examined.
Time frame: baseline, 2 months
Modified Gingival Index (Trombelli et al. 2004)
0 = Normal gingiva; 1. = Mild inflammation - slight change in color and slight edema; 2. = Moderate inflammation - redness, edema and glazing; 3. = Severe inflammation - marked redness and edema, ulceration with tendency to spontaneous bleeding. will be evaluated visually
Time frame: baseline, 2 months
Bleeding on probing (BOP)
All six sites of all teeth are assessed with regard to whether probing elicits bleeding (+) or not (-). The severity of gingivitis is expressed as a percentage. \- no bleeding upon probing (not recorded) \+ bleeding upon probing Calculation: BOP= Number of bleeding sites x100/ Number of sites evaluated will be evaluated visually and used a UNC-15 mm "University of North Carolina" periodontal probe
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Time frame: baseline, 2 months