Short Term Refractive and Ocular Parameter Changes After Topical Atropine

Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation96 enrolled

Overview

In order we had designed a prospective clinical trial. Spherical equivalent refractive error (SER), axial length (AL), mean keratometric value (Mean-K), anterior chamber depth (ACD), and intraocular pressure (IOP) were measured at baseline and one week after topical use of 0.125% atropine. Postcycloplegic changes of refractive error and ocular parameters were evaluated, and their correlations were analyzed with multiple linear regression models.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Myopia, Left Eye

Interventions

0.125% AtropineDRUG

patients used 0.125% atropine eyedrop per night before sleep for 7 days.

Eligibility

Sex: ALLMin age: 3 YearsMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients who had an SER of -0.5 diopters or less in their eyes. Exclusion Criteria: * Patients who had already been undergoing cycloplegic treatment for myopia before.

Outcomes

Primary Outcomes

SER

Spherical equivalent refractive error

Time frame: change from SER at 7 days

Secondary Outcomes

Axial length

Time frame: change from AL at 7 days

ACD

anterior chamber depth

Time frame: change from ACD at 7 days

IOP

intraocular pressure

Time frame: change from IOP at 7 days

Data from ClinicalTrials.gov

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