Experimental Human Infection With Neisseria Gonorrhoeae

Inclusion Criteria: 1. Healthy man \> / = 18 and \< 36 years old 2. Able and willing to be located easily by providing street address and telephone number (land line and/or cell phone number) 3. Willingness to provide written informed consent 4. Able and willing to attend all study visits including 6-day stay in the Clinical Translational Research Center (CTRC) during the trial (with ability to leave the unit during the day) and follow-up visit during the week after treatment 5. Able and willing to abstain from all sexual activity until completion of the study and the follow-up test for gonorrhea is negative 6. Acceptable medical history by screening evaluation 7. No clinically significant abnormalities on physical exam 8. Urinalysis: leukocyte esterase, and White Blood Cell (WBC) values within normal limits (WNL) 9. CH50 WNL 10. Urine negative for chlamydia, gonorrhea, and trichomonas 11. Negative Human Immunodeficiency Virus (HIV), syphilis, and Hepatitis C (HCV) test results 12. Negative Hepatitis B (HBV) core and surface antibodies or results consistent with immunization (negative HBV core antibody/positive HBV surface antibody) 13. Denies history of Sexually Transmitted Infections (STIs) including gonorrhea, chlamydia, syphilis, HIV, HBV, and HCV 14. Denies history of bleeding diathesis 15. Denies history of seizures (due to reports of seizures with ciprofloxacin) 16. Denies history of cancer, except basal cell carcinoma of the skin \> 5 years ago 17. Denies history of drug abuse 18. Denies history of genitourinary surgery Exclusion Criteria: 1. Student or employee under the direct supervision of any of the study investigators 2. Any known immunodeficiencies including complement deficiency, antibody deficiency, chronic granulomatous disease or Human Immunodeficiency Virus (HIV) infection 3. Psychiatric disorders that, in the opinion of the physician, would interfere with the integrity of the data or volunteer safety 4. Unstable depression (defined as receiving either \< 3 months of the same medication (and dose) or a decompensating event during the previous 3 months) or depression that, in the opinion of the investigator, will compromise the subject's ability to comply with protocol requirements 5. Heart murmur or heart disease 6. Anatomic abnormality of the urinary tract 7. Any antibiotic treatment in the past 30 days, or azithromycin in the past 60 days 8. Self-reported chemotherapy within the past year 9. Current steroid use, except for topical application 10. Allergy to penicillin, cephalosporins or ciprofloxacin or to lidocaine 11. Treatment with medications in the previous month that are contraindicated with cefixime, ceftriaxone or ciprofloxacin and that cannot be withheld for the single doses given in this study 12. Serum creatinine level \< 0.7 or \> 1.75 mg/dL and deemed clinically significant by the study physician 13. Serum ALT level \< LLN or \> 105 U/L and deemed clinically significant by the study physician 14. WBC count \< 2.5 or \> 15.0 x 10\^9/L and deemed clinically significant by the study physician 15. Absolute neutrophil count (ANC) \< 1.5 or \> 7.5 x 10\^9/L and deemed clinically significant by the study physician Exception: For African Americans, ANC values as low as 1.3 x 10\^9/L will be allowed (25) 16. Hemoglobin level \< 12.0 g/dL or above ULN and deemed clinically significant by the study physician 17. Urinalysis: Qualitative protein level \> 1+ or RBC count \> 10/hpf Medications not permitted with cefixime or ceftriaxone: 1. Warfarin 2. Probenecid 3. Aspirin 4. Diuretics such as furosemide 5. Aminoglycoside antibiotics 6. Chloramphenicol Medications not permitted with ciprofloxacin: 1. Tizanidine 2. Theophylline 3. Warfarin 4. Glyburide 5. Cyclosporine 6. Probenecid 7. Phenytoin 8. Methotrexate 9. Antacids, multivitamins, and other dietary supplements containing magnesium, calcium, aluminum, iron or zinc 10. Caffeine-containing medications 11. Sucralfate or didanosine chewable or buffered tablets