A prospective cohort study investigating the effect of the formation of gut microbiome on the neonatal disease and the prognosis of neurodevelopment in preterm infants.
The purpose of this study was to investigate the effect of the formation of gut microbiome on the neonatal disease and the prognosis of neurodevelopment in preterm infants.
Study Type
OBSERVATIONAL
Enrollment
47
Seoul National University Hospital
Seoul, South Korea
The distribution rate of intestinal microbiome of stool by K-mer based taxonomic assignment
Comparison of gut microbiome with 16s RNA gene specific sequencing in stool, breast milk, gastric juice
Time frame: within 24 hours after birth
The distribution rate of intestinal microbiome of stool by K-mer based taxonomic assignment
Comparison of gut microbiome with 16s RNA gene specific sequencing in stool, breast milk, gastric juice
Time frame: 2 weeks after birth
The distribution rate of intestinal microbiome of stool by K-mer based taxonomic assignment
Comparison of gut microbiome with 16s RNA gene specific sequencing in stool, breast milk, gastric juice
Time frame: 3~5 weeks after birth
The distribution rate of intestinal microbiome of stool by K-mer based taxonomic assignment
Comparison of gut microbiome with 16s RNA gene specific sequencing in stool, breast milk, gastric juice
Time frame: at 37~40 weeks of postmenstrual age
Brain MRI
white matter injury
Time frame: at 37~40 weeks of postmenstrual age
Bayley scales of infant and toddler development, third edition
For neurodevelopmental screening, Bayley scales of infant and toddler development, third edition yields composite scores for each cognitive, language, motor. It is considered normal when \>85. Developmental delay is diagnosed when the mean result is below 85. Neurodevelopmental screening is considered normal when a child achieves these all.
Time frame: at 18~24 months of corrected age
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Incidence of major morbidity
Major morbidity such as bronchopulmonary dysplasia, periventricular leukomalacia, retinopathy of prematurity
Time frame: at 36~40 weeks of postmenstrual age
Comparison of inflammation markers
Comparison of inflammation markers such as Interleukin(IL)-1 beta/IL-1F2, IL-6, IL-8/CXCL8, Tumor necrosis factor(TNF)-alpha, etc.
Time frame: with in 24 hours after birth, in 2 weeks, in 3~5 weeks, at 37~40 weeks of postmenstrual age
Comparison of short chain fatty acid at 4 period
Comparison of short chain fatty acid in stool and blood at 4 period
Time frame: with in 24 hours after birth, in 2 weeks, in 3~5 weeks, at 37~40 weeks of postmenstrual age