DELPhI acquisition and analysis software, a QuantalX Neuroscience development, which is designed to measure, analyze, and display brain electrical activity of human electroencephalogram (EEG), to transcranial magnetic stimulation (TMS), will be used to evaluate different psychiatric conditions.
Psychiatric conditions requiring pharmaceutical treatment include Schizophrenia and other psychotic disorders, Major depressive disorder, Bi-polar disorder, Post Traumatic Stress Disorder, Obsessive Compulsive Disorder and anxiety disorders. To date none of the psychiatric conditions mentioned diagnosis' relies on an imaging or other quantitative technique. Diagnosis and treatment prescription in the psychiatric clinic still relies on subjective reports and physician assessment of symptoms. Trans-cranial magnetic stimulation (TMS) is a noninvasive brain stimulation method that allows to study human cortical function In-vivo. Using TMS for examining human cortical functionality is enhanced by combining TMS with simultaneous registration of electroencephalograph (EEG). EEG provides an opportunity to directly measure the cerebral response to TMS, measuring the cortical TMS Evoked potential (TEP), is used to assess cerebral reactivity across wide areas of neo-cortex. Studies integrating TMS with EEG (TMS-EEG) have shown that TMS produces waves of activity that reverberate throughout the cortex. and that are reproducible and reliable thus providing direct information about cortical excitability and connectivity with excellent time resolution. By evaluating the propagation of evoked activity in different behavioral states and in different tasks, TMS-EEG has been used to causally probe the dynamic effective connectivity of human brain networks.
Study Type
OBSERVATIONAL
comparison of DELPhI parameter of Plasticity in psychiatric population to healthy norms.
Comparison of DELPhI parameters of Plasticity in patients, in comparison to healthy norms. Parameters will be analyzed for their temporal and special components.
Time frame: through study completion, an average of 1 year
comparison of DELPhI parameter of Connectivity in psychiatric population to healthy norms.
Comparison of DELPhI parameters of Connectivity in patients, in comparison to healthy norms. Parameters will be analyzed for their temporal and special components.
Time frame: through study completion, an average of 1 year
correlation between DELPhI parameters and symptom severity.
Self-control analysis of the change in DELPhI parameters following change in treatment prescription or any other treatment at different time points compared to base-line. Correlation to symptom severity will be assessed.
Time frame: through study completion, an average of 1 year
Cluster analysis of Plasticity and connectivity in relation to medical treatment and clinical diagnosis.
Cluster subjects by each plasticity and connectivity vs. medical treatment and clinical diagnosis.
Time frame: through study completion, an average of 1 year.
characterization of the change in Plasticity following change of treatment regimen
characterization of the change in Plasticity of Plasticity following change of treatment regimen.
Time frame: through study completion, an average of 1 year.
characterization of the change in Connectivity following change of treatment regimen
characterization of the change in Connectivity following change of treatment regimen.
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Time frame: through study completion, an average of 1 year.