OPtimisation of Surgical Repair for Treating Insufficiency of the MItral Valve - Safety Evaluation

Inclusion Criteria: Patients 1. with symptomatic severe Mitral Regurgitation (Carpentier's classification Type I or II P2) or in asymptomatic subjects with preserved Left Ventricle function and new onset of atrial fibrillation or pulmonary hypertension; 2. with EuroScore II \< 4; 3. with Left Ventricle Ejection Fraction ≥ 55%; 4. with normal coronary angiogram (no significant lesions); 5. in satisfactory condition, based on the physical exam and investigator's experience, with a life expectancy above one year after the intervention; 6. willing to sign the informed consent; 7. willing to undergo all medical follow-up, echocardiography examinations and laboratory tests planned for the clinical investigation. Exclusion Criteria: Patients 1. of age \< 18 years; 2. who are pregnant; 3. nursing mothers; 4. who require undergoing MRI examination; 5. involved in any other clinical investigation for drugs or devices; 6. with previous cardiac surgery or diaphragmatic lesion or previous hepatic surgery; 7. needing acute intervention; 8. with active endocarditis (or having had active endocarditis in the last three months); 9. with active myocarditis; 10. with heavily calcified mitral annulus or mitral valve anatomy with a high risk of valve replacement instead of valve repair; 11. needing any cardiac surgery other than mitral repair, tricuspid valve annuloplasty, pacemaker implantation (epicardial), exclusion of left appendage (with device or surgically) and Maze (or PVI) procedure; 12. with severe pulmonary hypertension (systolic pulmonary artery pressure at rest \>65 mmHg); 13. with LV Ejection Fraction \< 55%; 14. with creatinine level \> 2.0 mg/100ml; 15. with echocardiographic measurements predicting SAM (see specific echocardiography protocol); 16. unable to take anticoagulation medications; 17. with a known untreatable allergy to contrast media or nickel; 18. with a major or progressive non-cardiac disease that, in the investigator's experience, results in a life expectancy shorter than 1 year, or for whom the implant of the device produces an unacceptable increase of risk; 19. having had an acute preoperative neurological deficit, myocardial infarction, or cardiac event that has not returned to baseline or stabilized ≥ 30 days prior to the planned surgical procedure. 20. unable to understand and sign the ICF in absence of legal protection 21. unable to read and write 22. anticipated ring size very small (26mm) or very large (36mm)