Raltegravir One Thousand Two Hundred vs Darunavir-cb in Immnunosupressed Patients: ROTDIP Study

Inclusion Criteria: * Subjects ≥ 18 years of age. * HIV-1 infection. * Naive to antiretroviral treatment. * CD4 count at the beginning of the study \<200 cells/μl. * Estimated glomerular filtration ≥ 50 mL / min, according to the formula CKD-EPI. * Grant Informed Consent in writing to participate in the study Exclusion Criteria: * Breastfeeding, pregnant or women in childbearing age who do not commit to maintain barrier contraceptive measures during the trial. * Concomitant use of any drug with possible pharmacological interaction with the study drugs that it is advisable to "avoid" through the database for interactions at the University of Liverpool (www.hiv-druginteractions.org). * Previous use of any antiretroviral for HIV infection. * Resistance to the study drugs, or presence of any contraindication to use it. The inclusion in the study can be carried out before receiving the result of the resistance test. Once it is received, in case of presenting any mutation of resistance to drugs of the indicated regimen, the patient will be removed from the study and will be offered the best available treatment for their medical condition at that time. * Therapies that include interferon, interleukin-2, cytotoxic chemotherapy or immunosuppressants at the entrance to the study. * Current consumption of alcohol or other substances that at the discretion of the investigator may interfere with subject's treatment compliance. * Subjects who currently participate in any other clinical trial using a research product, with the exception of studies in which the treatment studied has been stopped for more than 12 weeks. * AIDS event in diagnosis of HIV infection or in the 3 months prior to the inclusion of the study. * Suspected severe hepatopathy (grades B or C of the Child-Pugh classification), of any origin, according to the clinician. * Any other clinical condition or previous treatment that, in the investigator's judgment, makes the subject unsuitable for the study or unable to comply with the dosage requirements.