This study will compare continuous intravenous lidocaine against single-injection transversus abdominis plane (TAP) block as a modality for postoperative analgesia in kidney transplant surgery.
This study is a non-inferiority trial designed to assess the analgesic efficacy of an intravenous (IV) lidocaine infusion against single-injection transversus abdominis plane (TAP) block in patients undergoing kidney transplant surgery. The investigators propose a study of 124 subjects randomized into two groups. The control group will receive a TAP block. The study group will receive a continuous IV lidocaine infusion. The investigators hypothesize that there will be no statistically significant difference in postoperative opioid consumption between the two groups in the first 24 hours.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
124
Single-injection transversus abdominis plane block with 30 mL of 0.25% Bupivacaine with 1:400,000 epinephrine
Continuous intravenous lidocaine infusion
Virginia Mason Medical Center
Seattle, Washington, United States
RECRUITINGOpioid Consumption
Total opioid utilization
Time frame: 0-24 Hours
Pain Scores
Numerical Rating Scale Pain Scores (Range: 0-10, where 0 is no pain and 10 is the worst pain)
Time frame: 0-48 Hours
Opioid Consumption
Total opioid utilization
Time frame: 24-48 Hours
Opioid-Related Adverse Events
Nausea, Vomiting, Pruritis, Respiratory Depression, Constipation
Time frame: 0-48 Hours
Block/Infusion-Related Adverse Events
Local Anesthetic Systemic Toxicity
Time frame: 0-48 Hours
Opioid Usage
Use of prescribed opioids
Time frame: 30 days from discharge
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.