Dose Individualization of Antineoplastic Drugs and Anti-Infective Drug in Children With Hematoplastic Disease

change of plasma concentration of bortezomib

To detect the plasma concentrations of bortezomib after administration

Time frame: at(0-0.5)h,(0.5-3)h,(24-48)h,(48-72)h hours after administration

change of plasma concentration of eltrombopag

To detect the plasma concentrations of eltrombopag after administration

Time frame: at (0.5-3)h,(3-6)h,(10-14)h,(20-24)h hours after oral administration

change of plasma concentration of imatinib

To detect the plasma concentrations of imatinib after administration

Time frame: at (0.5-2)h,(2-4)h,(10-14)h,(20-24)h hours after oral administration

change of plasma concentration of dasatinib

To detect the plasma concentrations of dasatinib after administration

Time frame: at(0-0.5)h,(0.5-3)h,(10-14)h,(20-24)h hours after oral administration

change of plasma concentration of pegaspargase

To detect the plasma concentrations of pegaspargase after administration

Time frame: at Day-1,Day(0-1),Day(3-5),Day(8-10),Day(13-14) after administration

plasma concentration of anti-infective drug

To detect the plasma concentrations of anti-infective drug after administration

Time frame: through study completion, an average of 14 days