Efficacy and Systemic Safety of Netarsudil 0.01%, 0.02%, 0.04% Relative to Placebo in Subjects With Open-angle Glaucoma or Ocular Hypertension in Japan

Inclusion Criteria: 1. Must be 20 years of age or older 2. Diagnosis of open-angle glaucoma (OAG) or ocular hypertension (OHT) in both eyes. (OAG in one eye and OHT in the fellow eye is acceptable) 3. BCVA 0.1 or better in decimal unit using Landolt-C chart or its equivalent 4. Able and willing to give signed informed consent and following study instructions Exclusion Criteria: 1. Clinically significant ocular diseases 2. Pseudoexfoliation or pigment dispersion component glaucoma, history of narrow angle closure glaucoma or narrow angles 3. Previous glaucoma intraocular surgery 4. Refractive surgery in either eye 5. Ocular trauma 6. Ocular infection or inflammation 7. Known hypersensitivity to benzalkonium chloride or excipient of netarsudil ophthalmic solution 8. Cannot demonstrate proper delivery of the eye drop 9. Clinically significant abnormalities in screen lab tests 10. Clinically significant systemic disease 11. Participation in any investigational study within 30 days of screening 12. Women of child-bearing potential who are pregnant, nursing, planning a pregnancy or not using a medically acceptable form of birth control