High flow nasal cannula oxygen therapy has been widely used in critically ill patients. Despite effectiveness of high flow nasal cannula as a treatment, optimal methods to withdrawal high flow nasal cannula after recovery from preexisting conditions has not been investigated to date. In this study, we will evaluate the efficacy and safety of three different weaning methods in patients with high flow nasal cannula oxygen therapy.
Comparison of three weaning strategies: flow reduction first versus fraction of inspired oxygen (FiO2) first versus simultaneous reduction
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Enrollment
100
-10L/min q 1hr
\- 0.1 q 1hr
-10L/min and -0.1 q 1hr
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, South Korea
Time to weaning success
The time to successfully remaining off high flow nasal cannula
Time frame: up to 2 weeks
weaning success or failure rate
Success or failure rate to wean off high flow nasal cannula
Time frame: up to 2 weeks
change of arterial partial pressure of oxygen, carbon dioxide, and pH
changes of arterial blood gas analyses
Time frame: up to 2 weeks
intolerance rate
intolerance to high flow nasal cannula
Time frame: up to 2 weeks
hospital length of stay
hospital length of stay
Time frame: during hospital admission, up to 12 weeks
In-hospital mortality
all cause mortality
Time frame: during hospital admission, up to 12 weeks
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