The study is aimed at verifying if a pulmonologist can reliably assess the tumor burden for the extractive molecular analysis in ROSE samples obtained with endoscopic sampling procedures from intrathoracic lymphadenopathy and pulmonary nodules.
Study Type
OBSERVATIONAL
Enrollment
164
Specimens obtained with endoscopic sampling procedures are stained with a rapid method (i.e., Diff Qui) and submitted to on-site cytologic review
Maggiore Hospital
Bologna, Emilia-Romagna, Italy
Policlinico S. Orsola
Bologna, Italy
Accuracy with which a pulmonologist can assess the tumor burden on ROSE slides
The outcome 1 will be measured by verifying the agreement between the pulmonologist judgment and the molecular pathologist judgment, the latter being the gold standard
Time frame: The time frame is the duration of each bronchoscopy with endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for each patient enrolled
Interobserver agreement between pulmonologist, pathologist and molecular pathologist in then assessment of the tumor burden on ROSE slides
The outcome 2 will be measured by verifying the agreement between the 3 professionals, using the judgment of the molecular pathologist as gold standard
Time frame: The time frame is the duration of each bronchoscopy with endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for each patient enrolled
Accuracy with which a pulmonologist can identify malignancy on ROSE samples
The outcome 3 will be measured by verifying the agreement between pulmonologist and pathologist, the latter being the gold standard
Time frame: The time frame is the duration of each bronchoscopy endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for each patient enrolled
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.