Tongji-Ezhou Study

Huazhong University of Science and Technology10,000 enrolled

Overview

Tongji-Ezhou study (TJEZ) is a prospective cohort study launched at 2013 in EZhou city, Hubei province, with the goal of recruiting and assessing 10,000 individuals and then following them for at least 2 decades. In addition, blood samples would be collected every 3-5 years among 6000 of them to investigate the nutritional biomarkers and potential determinants of chronic diseases such as obesity, type 2 diabetes, metabolic syndrome, and cardiovascular disease.

Study Type

OBSERVATIONAL

Enrollment

10,000

Conditions

Diabetes Cardiovascular Diseases Obesity Metabolic Syndrome Nutritional and Metabolic Diseases Environmental Exposure Risk Factor, Cardiovascular

Eligibility

Sex: ALLMin age: 20 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * (i) permanent residence in Ezhou district (minimum of 9 months); (ii) written informed consent; (iii) age ≥ 20 years old at the time of enrolling in the study. Exclusion Criteria: * (i) with chemotherapy or radiotherapy for cancer and other severe diseases.

Outcomes

Primary Outcomes

Incidence of diabetes

Type 2 diabetes was diagnosed when FPG ≥ 7.0 mmol/L and/or OGTT2h ≥ 11.1 mmol/L, or using diabetic medication (self-report).

Time frame: 5 years

Incidence of metabolic syndrome

Metabolic syndrome is defined as using the updated National Cholesterol Education Program/Adult Treatment Panel III criteria for Asian Americans. These criteria require three or more of the following components: (1) central obesity (waist circumference of ≥90 cm for men or ≥80 cm for women), (2) triglycerides of ≥1.7 mmol/L, (3) HDL-C of \<1.03 mmol/L for men or \<1.30 mmol/L for women, (4) blood pressure of ≥130/85 mmHg or on medication for hypertension, and (5) fasting glucose of ≥5.6 mmol/L.

Time frame: 5 years

Diabetic complications

Development of diabetic complications

Time frame: mean follow up of 10 years

Incidence of cardiovascular diseases

Cardiovascular death, stroke, myocardial infarction, heart failure