In this randomized double-blind, placebo-controlled, crossover pilot trial, we evaluated the effects of 7-day H2 inhalation on exercise performance outcomes and serum hormonal and inflammation profiles in a cohort of young men and women.
All participants were allocated to receive either gaseous hydrogen (4%) or placebo (room air) by 20-min once-per-day inhalation for 7 days, with wash-out period of 7 days to prevent the residual effects of interventions across study periods. The primary treatment outcome was the change in running time-to-exhaustion from baseline to day 7. Additionally, assessment of other exercise performance endpoints and clinical chemistry biomarkers were performed at baseline and after 7 days after each intervention.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
20
FSPE Applied Bioenergetics Lab
Novi Sad, Vojvodina, Serbia
Change in exercise performance
Running time-to-exhaustion
Time frame: Change from baseline running time-to-exhaustion at 7 days
Change in exercise performance
Maximal voluntary isometric strength
Time frame: Change from baseline maximal voluntary isometric strength at 7 days
Change in clinical chemistry biomarker
Insulin
Time frame: Change from baseline serum insulin at 7 days
Change in clinical chemistry biomarker
Ghrelin
Time frame: Change from baseline serum ghrelin at 7 days
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