The purpose of this randomized pilot study is to compare the efficacy of double oocyte retrieval vs. conventional antagonist ovarian stimulation protocol in poor prognosis patients undergoing in vitro fertilization (IVF) or intra-cytoplasmic sperm injection (ICSI).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
48
In the study group, 225 IU of recombinant FSH (rFSH) will continue after the first oocyte retrieval (OR). Antagonist administration will be initiated when at least one follicle measuring ≥14 mm will be present in the ultrasound. If one or more follicles ≥17 mm are observed, patients will undergo a second triggering with human chorionic gonadotropin (hCG) 5000 IU and a second OR will be performed. In case of patients with no follicular development following 10 additional days of rFSH post-OR
UZ Brussel
Brussels, Jette, Belgium
Number of MII Oocytes Retrieved Between the Two Arms
number of mature (or metaphase II, MII) oocytes retrieved during oocyte retrieval
Time frame: 1 month
Number of Preovulatory Follicles
number of follicles ≥11m on the day of final oocyte maturation trigger
Time frame: 1 month
Number of Cumulus Oocyte Complexes (COCs) Retrieved
number of COCs retrieved at oocyte retrieval
Time frame: 1 month
Number of Oocytes Fertilized
number of fertilized oocytes at day 1 after oocyte retrieval
Time frame: 1 month
Total Number of Available Embryos
number of available embryos at day 3 or day 5 after oocyte retrieval, good quality and therefore transferable
Time frame: 1 month
Duration of Ovarian Stimulation
number of days of ovarian stimulation
Time frame: 1 month
Clinical Pregnancy Rates
clinical pregnancy rate
Time frame: 4 months
Live Birth Rates
number of live births
Time frame: 12 months
Cumulative Live Birth Rates
defined as the first live birth following the transfer of fresh and subsequent frozen-thawed embryos
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Time frame: 24 months