This study aims to assess the diagnostic feasibility and diagnostic performance of a new fast MR sequence EPIMix for neuroradiological evaluation in comparison to computed tomography of brain in pediatric population.
The study aims to assess the feasibility of fast MR sequence for neuroradiological evaluation in comparison to computed tomography of brain in pediatric population. Imaging quality is analysed with regards to artefacts and lesion conspicuity as well as its diagnostic potential in rendering a probable diagnosis. The primary study aim is to define feasibility and the AUC for diagnostic performance of minute MRI compared to computed tomography. Included patients are children age 4-18 with suspicion of cerebral pathology with referral to elective computed tomography of the brain. Study participants are in addition to computed tomography investigated during same day at 3T MR.
Study Type
OBSERVATIONAL
Enrollment
15
Brain MRI without intravenous contrast
Karolinska University Hospital
Stockholm, Sweden
Tolerance of a new fast MR method in children
Number of aborted MR
Time frame: At 0 hours
Diagnostic potential
Diagnostic accuracy to categorize scan as normal or abnormal on a five point Likert scale (1 - definitely normal, 2 - Probably normal, 3 - Indeterminate, 4 - Probably abnormal, 5 - Definitely abnormal) compared to abnormal/normal brain CT.
Time frame: At 0 hours
Lesion classification
Classification into disease categories (Neoplastic, Ischemic, Hemorrhagic, Infection, Neuroinflammation, Hydrocephalus, Congenital malformation, Indeterminate)
Time frame: At 0 hours
Lesion location determination
Anatomical localization of abnormality (Cerebrum, Cerebellum, Brainstem, Intraventricular, Subarachnoid space including basal cisterns, Intra-orbital, Skull/Skull base/dural, Other)
Time frame: At 0 hours
Diagnostic imaging quality
Diagnostic imaging quality (5 point Likert scale; 1 - Excellent diagnostic imaging quality, 2 - Good diagnostic imaging quality, 3 - Sufficient diagnostic imaging quality, 4 - Restricted diagnostic imaging quality, 5 - Poor diagnostic imaging quality)
Time frame: At 0 hours
Lesion description
For example effect on brain parenchyma and size
Time frame: At 0 hours
Diagnostic confidence
Five point Likert scale (Very confident, Predominantly confident, Fairly confident, Only slightly confident, Not at all confident)
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Time frame: At 0 hours
Clinical diagnostic summary report
Text (one sentence summary of the finding including type of lesion and location)
Time frame: At 0 hours
Ability to rule out diseases
A list of diseases. Number of positive versus negative cases for each investigation (including: Tumor, Abscess, Parenchymal Haemorrhage, Acute Ischemia, Hydrocephalus, Neuroinflammation, Subarachnoid hemorrhage, Extraaxial fluid collection)
Time frame: At 0 hours
Artefacts
Artefacts and impact (Motion, Beam hardening, Other) defined as; Not present, Not affecting diagnostic confidence, Degrading diagnostic confidence)
Time frame: At 0 hours