The aim of this observative, prospective study is to evaluate if and to what extent glycocalyx damage/microcirculation data at admission in the ICU as well as during ICU stay can be predictive of mortality and clinical course in patients presenting with the suspicion of sepsis/septic shock. Therefore, the enrollment of ca 100 ICU patients is planned.
Study Type
OBSERVATIONAL
Enrollment
100
Non-invasive assessment of endothelial glycocalyx dimensions.
Universitiy Hospital Muenster
Münster, Germany
Predictive value of glycocalyx thickness regarding clinical course.
Glycocalyx thickness measured with the use of GlycoCheck System (Perfused Boundary Region - PBR, in µm). Clinical course will be estimated with the use of e.g. Sequential Organ Failure Assessment (SOFA) score (in points).
Time frame: Hospital stay, an expected time of 4 weeks.
Predictive value of glycocalyx thickness regarding mortality.
Glycocalyx thickness measured with the use of GlycoCheck System (Perfused Boundary Region - PBR, in µm).
Time frame: Hospital stay, an expected time of 4 weeks.
Correlation of glycocalyx thickness with disease severity.
Glycocalyx thickness will be measured with the use of GlycoCheck System (Perfused Boundary Region - PBR, in μm). Disease severity will be assessed with ICU scores (e.g. SOFA Score - pts)
Time frame: Hospital stay, an expected time of 4 weeks.
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