This is a two-part, open-label, healthy volunteer study. Part I will investigate the relative bioavailability of capsule and tablet formulations of RO7017773. Part II will explore how the taste of the tablet formulation is perceived with and without added sweetener/flavoring.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
24
Participants will receive 1 single oral dose of RO7017773 Phase I Capsule.
Participants will receive 3 single oral doses of unflavored RO7017773 Phase II tablet during Part 1, and 1 single oral dose of unflavored RO7017773 Phase II tablet during Part 2.
Participants will receive 1 single oral dose of sweetened/flavored RO7017773 Phase II tablet during Part 2.
PRA Health Sciences
Salt Lake City, Utah, United States
Maximum Observed Plasma Concentration (Cmax) of RO7017773 (Part 1)
Time frame: Day 1 to Day 5
Cmax of RO7017773 (Part 2)
Time frame: Day 1 to Day 5
Taste Assessment, as Measured by Taste Questionnaire (Part 2)
Taste was assessed using a questionnaire that asking participants to rate the overall taste of study drug dispersed in various vehicles on a scale from 1-5, with 1=no taste, and 5=very intense taste.
Time frame: Day 1
Taste Assessment, as Measured by Taste Questionnaire (Part 1)
Taste was assessed using a questionnaire that asking participants to rate the overall taste of study drug dispersed in various vehicles on a scale from 1-5, with 1=no taste, and 5=very intense taste.
Time frame: Day 1
Percentage of Participants With Adverse Events (AEs)
Time frame: Baseline through end of study (approximately 6 weeks)
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