The purpose of this clinical trial is to evaluate the pharmacokinetics and safety/tolerability after oral administration of CKD-375 and D387 in healthy adults.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
28
Maximum plasma concentration of Empagliflozin
Cmax of Empagliflozin
Time frame: Time Frame: 0 hour ~ 48 hour after drug administration
Maximum plasma concentration of Metformin
Cmax of Metformin
Time frame: Time Frame: 0 hour ~ 48 hour after drug administration
Area under the plasma concentration of Empagliflozin-time curve from time zero to time of last measurable concentration
AUClast of Empagliflozin
Time frame: Time Frame: 0 hour ~ 48 hour after drug administration
Area under the plasma concentration of Metformin-time curve from time zero to time of last measurable concentration
AUClast of Metformin
Time frame: Time Frame: 0 hour ~ 48 hour after drug administration
Area under the plasma concentration of Empagliflozin-time curve from time zero to infinity
AUCinf of Empagliflozin
Time frame: 0 hour ~ 48 hour after drug administration
Area under the plasma concentration of Metformin-time curve from time zero to infinity
AUCinf of Metformin
Time frame: 0 hour ~ 48 hour after drug administration
Time to reach maximum (peak) plasma concentration of Empagliflozin following drug administration
Tmax of Empagliflozin
Time frame: 0 hour ~ 48 hour after drug administration
Time to reach maximum (peak) plasma concentration of Metformin following drug administration
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Tmax of Metformin
Time frame: 0 hour ~ 48 hour after drug administration
Half-life of Empagliflozin
t1/2 of Empagliflozin
Time frame: 0 hour ~ 48 hour after drug administration
Half-life of Metformin
t1/2 of Metformin
Time frame: 0 hour ~ 48 hour after drug administration
Apparent clearance of Empagliflozin
CL/F of Empagliflozin
Time frame: 0 hour ~ 48 hour after drug administration
Apparent clearance of Metformin
CL/F of Metformin
Time frame: 0 hour ~ 48 hour after drug administration
Apparent volume of distribution of Empagliflozin
Vd/F of Empagliflozin
Time frame: 0 hour ~ 48 hour after drug administration
Apparent volume of distribution of Metformin
Vd/F of Metformin
Time frame: 0 hour ~ 48 hour after drug administration