Chronic fatigue is the most common and debilitating symptom in intensive care unit (ICU) survivors. Indeed, it has been widely reported that patients who stayed in ICU for prolonged periods report a feeling of tiredness for months to years after ICU discharge. This chronic fatigue affects their quality of life by decreasing their capacity to perform simple tasks of daily life. The aim of the present project is to determine whether deteriorated neuromuscular function (i.e. increased fatigability) is involved in this feeling of chronic fatigue. Because the causes of this feeling are multi-dimensional, a large battery of tests will allow us to better understand the origin of chronic fatigue. A better knowledge of chronic fatigue etiology will allow to optimize rehabilitation treatments to decrease the apparition/persistence of chronic fatigue and in fine improve life quality.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Quality of life Depression Physical pain Social provisions Quality of sleep
complete blood count and cytokine concentration
The maximal effort test with VO2max recordings will be assessed during the first visit to the laboratory.
assessment of sleep quality
* The maximum isometric force produced by the knee extensors will be measured on the ergometer * the intensity of muscular electrical activity recorded by surface electromyography * Peripheral nerve stimulation * Transcranial magnetic stimulation * Magnetic resonance imaging (optional)
Hôpital privé de la Loire
Saint-Etienne, France
voluntary maximum force reduction
Time frame: at 2 weeks
Neuromuscular function : cortical activity
Level of cortical activation and cortico-spinal excitability measured by transcranial magnetic stimulation
Time frame: at 2 weeks
Neuromuscular function : Peripheral function
Peripheral function by electrical nerve stimulation
Time frame: at visit 2
Maximal oxygen uptake (VO2max)
measured by effort test
Time frame: at 2 weeks
quality of sleep
measured by actigraphy
Time frame: at baseline
Quadriceps muscle volume (optional)
with Magnetic resonance imaging
Time frame: at 3 weeks
muscle dysfunction (optional)
measured by a Phosphorus 31 Nuclear magnetic resonance test
Time frame: at 3 weeks
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