Combination of Platelet-Rich Fibrin and Calcium Sulfate in Socket Augmentation

University of Malaya10 enrolled

Overview

This study evaluated the effectiveness of socket grafting material, combination of plate-rich fibrin and calcium sulfate. 5 subjects were grafted with this material, 5 subjects were grafted with combination of plate-rich fibrin and xenograft.

Calcium sulfate (CS), an alloplastic material, is widely accepted as a socket grafting material and undergoes rapid and complete resorption. Studies have shown that CS creates an osteoconductive lattice that stimulates bone ingrowth into a defect. PRF poses multiple growth factors, anti-inflammatory cytokines and adhesion molecules. It is biologically active up to one week. The combination of these 2 materials will serve as good grafting material for tooth socket, in order to preserve vertical and horizontal dimensions.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Tooth Extraction

Interventions

platelet-rich fibrin and calcium sulfateCOMBINATION_PRODUCT

platelet-rich fibrin and xenograftCOMBINATION_PRODUCT

Eligibility

Sex: ALLMin age: 25 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * maxillary premolar teeth requiring extraction * neighboring mesial and distal sound/restored teeth present * alveolar bone level (measured from periapical radiographs) more than 50% of the root length * age ranges from 25-55 years Exclusion Criteria: * bony fenestration of the socket wall confirmed from CBCT scan * acute signs of infection * periodontally compromised teeth * absence of buccal plates * any systemic disease which may hinder the healing process