Intravenous Infusion of Prostaglandins as Therapy in Patients With Anterior Non-arteritic Ischemic Optic Neuropathy

Inclusion criteria: * Patients of both sexes between the ages of 50 and 80, both inclusive. Patients with the first episode of ischemic optic neuropathy previous non-arteritic / NOIANA. Patients with NOIANA with an evolution time from the beginning of the clinic less than or equal to 15 days. * Potentially fertile patients should have a negative pregnancy test in serum (beta-HCG / human chorionic gonadotropin) or urine. * Patients who offer sufficient guarantees of adherence to the protocol. * Patients who give written informed consent to participate in the study. Exclusion Criteria: * Patients with previous optic of any etiology in the affected eye. * Patients with previous diagnosis or symptoms at the time of arteritis of the temporal artery. * Patients with optic neuropathy with bilateral clinical presentation of any etiology. * Patients with loss of vision due to acute hypotension in the context of a surgical intervention, acute hemorrhage or hemodynamic shock. * Patients with severe loss of previous vision in the eye affected by ophthalmologic causes: severe cataract, glaucoma or intraocular pressure greater than 30 millimeters of mercury, severe diabetic retinopathy, macular degeneration associated with severe age. * Patients with clinical onset in the month following major non-ocular or intraocular surgery * Patients with abnormal elevation of CRP / C-reactive protein (\> 2 times the upper limit of normal) * Patients with creatinine levels above 1.5 mg / dL. * Patients on steroid treatment in the month prior to the episode. * Patients under treatment with oral anticoagulants. * Patients on treatment with hydroxychloroquine, ethambutol, vigabatrin at any time before the episode. * Patients in whom the use of PGE1 (Alprostadil) is contraindicated: * Patients with participation in a clinical trial in the last 6 months. * Patients with inability to understand informed consent. * Pregnant patients, in the postpartum period or during the active lactation period. * Physically fertile patients