Morbidly obese patients undergoing either Roux en Y gastric bypass or sleeve gastrectomy were examined preoperatively, 3, 6, and 12 months after surgery. On each occasion, anthropometric data were collected, resting metabolic rate was measured, and the patients underwent a panel of cardiovascular examinations (heart rate variability, baroreflex sensitivity, heart ultrasound). Following that, they consumed a test meal and completed visual analog scales for the subjective assessment of hunger and fullness every 30 minutes for 3 hours. At the same time points, blood samples were collected for the consequent measurement of glucose, insulin, lipids, and gastrointestinal hormones.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
28
Bariatric surgery
Change in postprandial ghrelin responses
Change in the cumulative postprandial response for ghrelin
Time frame: 3, 6, and 12 months
Change in postprandial GLP-1 responses
Change in the cumulative postprandial response for GLP-1
Time frame: 3, 6, and 12 months
Change in postprandial PYY responses
Change in the cumulative postprandial response for PYY
Time frame: 3, 6, and 12 months
Change in weight
Change in weight (percentage of weight lost through each procedure)
Time frame: 3, 6, and 12 months
Change in postprandial glycemia
Change in the cumulative postprandial response for glucose
Time frame: 3, 6, and 12 months
Change in postprandial insulinemia
Change in the cumulative postprandial response for insulin
Time frame: 3, 6, and 12 months
Change in postprandial triglyceridemia
Change in the cumulative postprandial response for triglycerides
Time frame: 3, 6, and 12 months
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