The Impact on Survival of Neo-adjuvant Transarterial Chemoinfusion (TAI) for Patients With Beyond Milan Criteria BCLC Stage A/B Hepatocellular Carcinoma Who Underwent Hepatectomy

Inclusion Criteria: * older than 18 years old and younger than 75 years; * ECOG PS≤1; * proven hepatocellular carcinoma according patological examination or EASL/AASLD diagnostic criteria; * not previous treated for tumor; * the tumor was diagnosed as BCLC stage A/B and beyond Milan criteria; * no distant metastasis; * the lab test could meet: * neutrophil count≥2.0×109/L; * hemoglobin≥100g/L; * platelet count≥75×109/L; * serum albumin≥35g/L; * total bilirubin\<2-times upper limit of normal; * ALT\<3-times upper limit of normal; * AST\<3-times upper limit of normal; * serum creatine\<1.5-times upper limit of normal; * PT≤upper limit of normal plus 4 seconds; * INR≤2.2; * sign up consent. Exclusion Criteria: * cannot tolerate TAI or surgery; * distant metastasis exits; * known history of other malignancy; * be allergic to related drugs; * underwent organ transplantation before; * be treated before (interferon included); * known history of HIV infection; * known history of drug or alcohol abuse; * have GI hemorrhage or cardiac/brain vascular events within 30 days; * pregnancy.