Effect of High volumeHemodiafiltration on Lung Oxygenation

Inclusion Criteria: 1. ≥ 18 years 2. Severe sepsis defined by Quick SOFA score by presentation of 2 or more of the following criteria: * Mental clouding: decreased glasco coma scale GCS \< 15 * Hypotension: Systolic blood pressure \< 100 mmgH * Tachypnea: respiratory rate \> 22 breath/ minute Then serum lactate is analysed to confirm sepsis hypoperfusion if ≥ 2mmol/L 3. Organs dysfunction (including one of them respiratory failure). Organ dysfunctions are defined as following: Respiratory dysfunction (criteria for ARDS): * PaO2/FiO2 \<200 * Bilateral infiltrates in chest X-ray * Resistant hypoxemia * Tachypnoea (RR \> 40 breath/minute) * The need for invasive mechanical ventilation * Excluded cardiac causes of pulmonary edema CNS failure: * Decreased GCS ≥ 4 decreased points CVS dysfunction: * Sustained hypotension even on very high inotropes doses (Noradrenaline \>1µm/min)+ adrenaline\>1.5µm/min associated * with high CVP pressure \> 12 mmHg and not responding to fluid challenge test to exclude hypovolemia. * Cardiomegaly detected by either echocardiography assessment, or chest X-ray * Resistant frequent ventricular ectopics not explained by organic causes. Liver dysfunction: * Elevated total and direct bilirubin than double normal or basal levels * Elevated prothrombin time \> 17 seconds or INR \> 1.5 * Elevated liver enzymes \> triple normal level Renal dysfunction: * Decreased urine output \< 0.5 ml/kg. * Elevated creatinine level \> 164 µmol/L (1.5mg/dL). * Decreased creatinine clearance \<50ml/minute if available. Bone marrow depression: * Decreased platelets \< 90 X 103/µL * Decreased leukocytes \<4 X 103/µL * Decreased RBCs count \< 4 X 106/µL Exclusion Criteria: 1. Patient relatives' refusal 2. Pregnancy 3. Recent active internal hemorrhage 4. Not mechanically ventilated. 5. Hypersensitivity to the dialyser fluid