Assessment of Endocan Serum Levels in Patients With Behcet Disease

Benha University84 enrolled

Overview

The aim of our study was to assess serum endocan levels in patients with Behcet disease and to correlate it with various disease clinical and laboratory parameters of disease activity as well as carotid intima media thickness.

This study will be carried out on two groups: • Group (I): Forty two patients diagnosed to have Behcets disease fulfilling the International Criteria for BD . Group (II): including 42 age and sex matching healthy volunteers as control group. (A) Clinical evaluation 1. Complete history taking. 2. Thorough clinical examination including opthalmologic evaluation . 3. Disease activity using The Behcet's disease current activity form (BD-DAF) . (B) Laboratory assessment: All patients will be subjected to the following measurements: 1. ESR 2. CRP 3. CBC 4. liver and kidney function tests d) Serum Endocan level e)triglycrides f) cholestrol C) carotid intima media thickness

Study Type

OBSERVATIONAL

Enrollment

Conditions

Behçet

Interventions

measurement of serum endocanDIAGNOSTIC_TEST

measurement of serum levels of endocan

Eligibility

Sex: ALLMin age: 16 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * patients with Behcets disease fulfilling the International Criteria for BD . Exclusion Criteria: * infection * malignancy * other connective tissue disease * chronic liver disease * chronic kidney disease * Diabetes mellitus * hypertension * hyperlipidemia

Locations (1)

Benha University Hospital

Banhā, Qalyubia Governorate, Egypt

Outcomes

Primary Outcomes

the Behcet's disease current activity form (BDCAF)

One point is given to the presence of different organ involvement over the 4 weeks prior to assessment as follows: headache, mouth ulcers, genital ulcers, skin lesions , joint involvement , gastrointestinal symptoms , eye involvement , nervous system involvement , and major vessel involvement.The total score will be out of 12 and higher score indicates worse outcome. we will assess the relation between serum endocan level and BDCAF

Time frame: : through study completion, an average of 6 months

Erythrocyte sedimentation rate (ESR)

ESR measured in mm/1st hour by westergren method. we will assess the relation between serum endocan level and ESR

Time frame: : through study completion, an average of 6 months

C reactive protein (CRP)

CRP measured in mg/L using nephlometry. we will assess the relation between serum endocan level and CRP

Time frame: : through study completion, an average of 6 months

carotid intima media thickness

Color Doppler ultrasonography was performed for both common carotid arteries in a longitudinal orientation and measured with millimeter

Time frame: : through study completion, an average of 6 months

Data from ClinicalTrials.gov

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