Blood Eosinophil Measurements in Patients With Chronic Obstructive Pulmonary Disease

Universitair Ziekenhuis Brussel50 enrolled

Overview

This study will assess the within-day variation of blood eosinophils in patients with Chronic Obstructive Pulmonary disease (COPD) in stable state and determine if there is a correlation between the blood eosinophils and certain clinical parameters.

COPD is a heterogeneous disease, resulting in different phenotypes with varying clinical and pathophysiological characteristics. One of these pathophysiological features is chronic airway inflammation which can be eosinophilic of nature. Blood eosinophils could be an accessible biomarker for this eosinophilic inflammation. Eosinophil counts can fluctuate due to their short half-life in blood and due to a diurnal rhythm. More needs to be known about this diurnal rhythm and the different confounding factors and sources of within-subject variability of this biomarker.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Chronic Obstructive Pulmonary Disease

Interventions

Blood samplingOTHER

Blood sampling, Spirometry, Fraction exhaled Nitric Oxide

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients willing and able to give informed consent for participation in the study. * Age 18 years or older. * Diagnosis of COPD according to GOLD (Global Initiative for Chronic Obstructive Lung Disease): post-bronchodilator Tiffeneau index \<0.7), in a stable state of the disease. * A smoking history of \>10 pack-years Exclusion criteria: * Clinical diagnosis of asthma. * Use of systemic corticosteroids (oral, intravenous or infiltration) up to six weeks before inclusion. * Pregnancy. * A recent exacerbation of COPD (\<4 weeks).

Locations (1)

Universiatir Ziekenhuis Brussel

Brussels, Belgium

Outcomes

Primary Outcomes

Within-day within-subject level changes of blood eosinophils

Describe the within-day within-subject levels of blood eosinophils and determine the within-day within-subject variability of blood eosinophils

Time frame: 12 hours

Data from ClinicalTrials.gov

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