The proposed project tests the hypothesis that salivary alpha amylase concentration is a reliable biomarker of the effect of transdermal vagus nerve stimulation (tVNS) in humans.
The study examines the capacity of tVNS to alter the concentrations of salivary alpha amylase. Changes in salivary alpha amylase concentrations reflect alteration of CNS structures anatomically linked to the vagus, thus alertation of alpha amylase would indicate the efficacy of tVNS. This study is intended to study basic mechanisms and is not directed toward the treatment of any disease state. Particapants taking part in the study will spend about one hour in a single session.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
100
intermittent transdermal stimulation of the aurical vagus
Arkansas Tech University
Russellville, Arkansas, United States
Change in Salivary Alpha Amylase concentration.
Biomarker of autonomic arousal level
Time frame: Within single one hour session change in concentration immediately prior to and following stimulation and 5 minutes post-stimulation
Change in Heart Rate Variability.
Change in beat to beat interval.
Time frame: Within single one hour session change in heart rate variability immediately prior to and following stimulation period.
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