Glycocalyx Biomarkers in ARDS for Clinical Prognosis and Pulmonary Fibrosis

Southeast University, China336 enrolled

Overview

ARDS is a severe disease in ICU, and could induce high mortality. Glycocalyx is an important matrix construction which covers endothelial cells, it could protect endothelial cells injury and the glycocalyx biomarkers could predict pulmonary injury. Decorin is a member of the small leucine-rich proteoglycan (SLRP) family, contains a single glycosaminoglycan (GAG) chain and a core protein with 12 leucine-rich repeats. In the previous study, decorin is associated with cardiac and liver fibrosis, however, the effects of decorin on ARDS pulmonary fibrosis have not been clarified.

Study Type

OBSERVATIONAL

Enrollment

336

Conditions

ARDS, Human Endothelial Dysfunction Mechanical Ventilation Pressure High

Interventions

Glycocalyx measurement，respiratory mechanics measurement

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age \> 18yrs and \<80yrs 2. Meet ARDS Berlin definition 3. With mechanical ventilation Exclusion Criteria: 1. have chronic pulmonary disease 2. have use heparin or low molecular heparin or chondroitin sulfuric acid

Outcomes

Primary Outcomes

28 days mortality from patients involved in the study

Time frame: 28 days

Secondary Outcomes

CT and syndecan-1 to evaluate pulmonary fibrosis

pulmonary fibrosis evaluated by biomarker and CT

Time frame: 1mon, 3mon and 6 month

pulmonary function test to evaluate pulmonary function

pulmonary function evaluated by pulmonary function test