The Role of Physical Activity for Acute Exacerbations of COPD

Cantonal Hospital of St. Gallen42 enrolled

Overview

The investigators plan to study the association between physical activity, malnutrition and sarcopenia and the occurrence of acute exacerbations of COPD / the evolution of the COPD assessment test (CAT) over 1 year in a telehealthcare cohort of patients with COPD. The investigators hypothesize that malnutrition and/or sarcopenia at baseline and a decline in the fat-free mass index over time is associated with an increased rate of acute exacerbations of COPD and an increased CAT score meaning a higher risk for mortality, morbidity and impairment of quality of life.

Study Type

OBSERVATIONAL

Enrollment

Conditions

COPD

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * COPD GOLD stage B or higher * Written informed consent Exclusion Criteria: * Inability to provide written informed consent * Insufficient knowledge of the trial language

Locations (1)

Lung Center, Cantonal Hospital St. Gallen

Sankt Gallen, Canton of St. Gallen, Switzerland

Outcomes

Primary Outcomes

Rate of acute exacerbations of COPD

The primary outcome measure is the rate of acute exacerbations of COPD.

Time frame: 12 months

Secondary Outcomes

Physical activity

The rate of acute exacerbations of COPD will be correlated to the degree of physical activity measured using an activity tracker in everyday life. The following parameters will be recorded: * step count * distance travelled * calories burned

Time frame: 12 months

Fat-free mass index

The rate of acute exacerbations of COPD will be correlated to the fat-free mass index (FFMI) measured at baseline and after 6 and 12 months using bioelectrical impedance analysis (BIA).

Time frame: 12 months

Hand grip strenght

The rate of acute exacerbations of COPD will be correlated to the hand grip strength (HGS) measured at baseline and after 6 and 12 months using a dynamometer.

Time frame: 12 months

C-reactive protein

The rate of acute exacerbations of COPD will be correlated to the level of serum C-reactive protein (CRP) measured at baseline and after 6 and 12 months.

Time frame: 12 months

Total protein

The rate of acute exacerbations of COPD will be correlated to the level of total serum protein measured at baseline and after 6 and 12 months.

Time frame: 12 months

Albumin

The rate of acute exacerbations of COPD will be correlated to the level of serum albumin measured at baseline and after 6 and 12 months.

Data from ClinicalTrials.gov

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