Efficacy and safety evaluation of amiodarone and Nifekalant hydrochloride(NIF) for the treatment of ventricular tachycardia and ventricular fibrillation.
After patients are hospitalized, they will be treated as usual in addition to antiarrhythmic drugs. DC will be performed again according to normal procedures for patients who were ineffective. Arrhythmia drugs can only be used with nifekalant or amiodarone at random.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
756
Both groups were given conventional treatment except for arrhythmia drugs.Only nyficarine hydrochloride or amiodarone hydrochloride could be used according to random results, and the antiarrhythmic drugs should be replaced according to the protocol rules.
Both groups were given conventional treatment except for arrhythmia drugs.Only nyficarine hydrochloride or amiodarone hydrochloride could be used according to random results, and the antiarrhythmic drugs should be replaced according to the protocol rules.
Shenyang Military Region General Hospital
Shenyang, Liaoning, China
RECRUITINGThe rate of efficacy
Efficacy of drugs in each group within 24 hours after administration.
Time frame: 24 hours after administration.
The efficiency rate without adjusting the drug dose
number of patients who no longer relapse after using the drug / total number of patients in the group × 100%
Time frame: 24 hours after administration.
Number of electrical cardioversion used during the treatment
Number of electrical cardioversion
Time frame: 24 hours after administration.
The success rate of DC in patients with first invalid cardioversion in the two groups
Number of patients ewith valid DC after the first invalid DC / Total number of patients with first invalid DC in this group × 100%
Time frame: 24 hours after administration.
The average time from the start of administration to the last VT/VF no longer occurs
Patients who changed drugs will not be included statistics on this indicator.
Time frame: 24 hours after administration.
LVEF
Echocardiography
Time frame: Before administration, and 24h to 72h after the start of administration.
Survival rate
Survival rate of the two groups of patients
Time frame: 30 days after administration.
Number of ventricular tachycardia/ventricular fibrillation episodes
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Number of ventricular tachycardia/ventricular fibrillation episodes .
Time frame: Within 72 hours after drug administration.
The number of patients who need to continue the intravenous research drug after 24 hours in the two groups
The number of patients who need to continue the intravenous research drug after 24 hours in the two groups
Time frame: 24 hours after the start of the adminstration.
The effective rate of the drug in each group within 72 hours after administration
The effective rate of the drug in each group within 72 hours after administration.
Time frame: 72 hours after administration.