Observation of the Incidence and Natural History of MGUS in Patients Undergoing Weight Reduction Surgery

Inclusion Criteria: 1. Male or female patients 30 years or older planning to undergo weight reduction surgery or planning to enter into a physician monitored weight loss program 2. Patients must be obese, defined as a BMI ≥ 30 as calculated by the formula: weight in pounds / height squared x 703 = BMI 3. Subject consent and authorization for the release of health information must be obtained according to local institutional guidelines. 4. To remain in the study for the follow-up phase, the baseline screening test must indicate that a patient has MGUS. Exclusion Criteria: 1. No history of any malignancy except: adequately treated non-melanoma skin cancer, curatively treated in-situ cancer of the cervix, or other solid tumors curatively treated with no evidence of disease for ≥ 5 years. 2. No concurrent or planned participation in randomized trials of weight loss. 3. A patient will be excluded from the follow-up phase if the baseline screening test indicates they do not have MGUS