The aim of this study was to verify the prognostic value of functional kidney biomarkers on survival and renal function recovery in cardiac surgery patients with acute kidney injury.
Cardiac surgery-associated acute kidney injury (CSA-AKI) is the second most common type of AKI after septic AKI and is associated with increased mortality and morbidity. Few biomarkers were validated as outcome-specific biomarkers in patients developing AKI after cardiac surgery at initiation of RRT. This study was designed to not only verify the prognostic value of functional kidney biomarkers on survival, but also predict it severity in order to optimize clinical decision making with respect to dialysis initiation and discontinuation.
Study Type
OBSERVATIONAL
Enrollment
1,200
Indications for RRT were defined as previously reported. 1. Kidney Disease: Improving Global Outcomes (KDIGO) stage 2 ; 2. severe sepsis, persistence of hypotension (for more than 6 h) despite preload optimization and use of vasopressors or catecholamines (norepinephrine or epinephrine \>0.1 μg/kg/min), 3. refractory fluid overload (worsening pulmonary edema, PaO2/FiO2 \<300 mm Hg or fluid balance \>10% of body weight), 4. low probability of rapid renal recovery according to the judgment of the intensivists and nephrologists.
Zhongshan hospital, Fudan university
Shanghai, China
RECRUITING28-day mortality
Death from any cause at 28 days
Time frame: 28 days
Dependence on renal-replacement therapy at 28 days in survivors
Dependence on renal-replacement therapy was defined as surviving dependent on RRT
Time frame: 28 days
60- and 90-day mortality
Death from any cause at 60- and 90-days
Time frame: Up to 60 or 90 days
Length of stay in the ICU
the length of stay in the ICU
Time frame: Up to 90 days or ICU discharge
Length of stay in the hospital
the length of stay in the hospital
Time frame: Up to 90 days or hospital discharge
Adverse events
with a focus on the complications potentially related to acute kidney injury or renal-replacement therapy during the first 7 days after enrollment
Time frame: Up to 90 days
the number of days free of renal-replacement therapy, mechanical ventilation at 28 days
the number of days free of renal-replacement therapy, mechanical ventilation at 28 days
Time frame: 28 days
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