To compare prophylactic strategies of atrial fibrillation in patients with CAD and without AF.
Prospective, multicenter, randomized trial, intended to compare three prophylactic strategies of atrial fibrillation in patients with coronary artery disease and without history of atrial fibrillation. The study includes 4 groups of patients: Group I (conventional CABG) Group II (CABG + pulmonary veins isolation). Concomitant CABG and epicardial bipolar radiofrequency pulmonary veins isolation. Group III (CABG+ pulmonary veins isolation + amiodarone). Concomitant CABG and epicardial bipolar radiofrequency pulmonary veins ablation with administration of amiodarone in postoperative periode. Group IV (CABG+ amiodarone). Conventional CABG with administration of amiodarone in postoperative periode.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
280
Coronary artery bypass grafting
CABG+ prophylactic epicardial bipolar radiofrequency isolation of the pulmonary veins
CABG+PVI+amiodarone (CABG+RFA + class III antiarrhythmic drug- amiodarone)
Federal Centre of High Medical Technologies of the RF Ministry of Public Health, Kaliningrad, Russia.
Kaliningrad, Russia
RECRUITINGA.V. Vishnevsky National Medical Research Center of Surgery.
Moscow, Russia
RECRUITINGIncidence of atrial fibrillation after CABG
Time frame: Through study completion, an average of 1 year
Major cardiovascular and cerebral events (MACCE), including death, nonfatal myocardial infarction, repeated revascularization using PCI or CABG, transitory ischemic attack (TIA) or stroke.
Time frame: Through study completion, an average of 1 year
Sinus rhythm at the time of discharge of the patient from the hospital
Time frame: Through study completion, an average of 1 year
Duration of mechanical ventilation
Time frame: Through study completion, an average of 1 year
Incidence of implantation of the pacemaker
Time frame: Through study completion, an average of 1 year
Volume of intraoperative bleeding
Time frame: Through study completion, an average of 1 year
Time of CBP
Time frame: Through study completion, an average of 1 year
Time clamping of the aorta
Time frame: Through study completion, an average of 1 year
Length of stay in the intensive care unit
Time frame: Through study completion, an average of 1 year
Duration of the hospitalization
Time frame: Through study completion, an average of 1 year
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