The objective of this study is to compare the clinical outcome of Non-ST-elevation myocardial infarction (NSTEMI) and ST-elevation myocardial infarction (STEMI) patients with non-obstructive, non-culprit coronary lesions and either presence or absence of vulnerable plaque characteristics as assessed by optical coherence tomography (OCT).
Despite major advances in the treatment of acute coronary syndromes a large proportion of patients is still at risk for new coronary events after experiencing an acute coronary syndrome (ACS). Detection of residual vulnerable plaques after ACS using OCT potentially identifies patients at high risk for new coronary events. However, no prospectively collected data on the prognostic power of OCT for plaque rupture are available at this moment. To design trials aimed to reduce events in patients with vulnerable plaques it is required to collect such prospective data on the relation between OCT derived characteristics of vulnerability and clinical outcome.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
438
Optical coherence tomography imaging is performed of non-obstructive, non-culprit coronary lesions to assess plaque morphology.
Radboudumc
Nijmegen, South Holland, Netherlands
Major Adverse Cardiac Events
Composite of all cause mortality, non-fatal myocardial infarction or unplanned revascularization.
Time frame: 2 years
Major Adverse Cardiac Events
Composite of all cause mortality, non-fatal myocardial infarction or unplanned revascularization.
Time frame: 1 year
Major Adverse Cardiac Events
Composite of all cause mortality, non-fatal myocardial infarction or unplanned revascularization.
Time frame: 5 years
Target lesion Failure
Cardiac death caused by target lesion, myocardial infarction caused by target lesion, revascularisation of target lesion
Time frame: 2 and 5 years
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